It has been demonstrated that HuR binds to the 3′ UTR of cyclin A2 and stabilize the mRNA of cyclin A2 in CRC cells in a cell cycle-dependent manner, as cyclin A2, a cofactor of cyclin dependent kinase 2 (CDK-2) enhances tumor cells progression through the S phase [12]. The gene discussed is CCNA2; the disease is colorectal carcinoma.