This confirms previous findings(Mazzilli et al., 2023;El-Kashlan et al., 2015;La Vignera et al., 2017)demonstrating testicular dysfunction and male infertility in hypothyroidism.Hyperprolactinemia might be the link between the observed primary hypothyroidism andhypogonadotropic hypogonadism (Brown etal., 2023) since BPF has been shown to increase circulatoryprolactin (Odetayo & Olayaki, 2023).Hypothyroidism is associated with an increase in circulatory TRH, which in turnincreases circulatory prolactin (Tashjian Jret al., 1971). This evidence concerns the gene TRH and male infertility.