Our findings revealed three genes that are prognostic indicators for glioma: BRCA1, HDAC1, and RANGAP1. Among them, some studies have shown that BRCA1 may affect the development of glioma and patient prognosis by regulating the TGF-β/PI3K/AKT/mTOR signaling pathway [25]. Here, AKT1 is linked to central nervous system cancer.