A large, one‐of‐a‐kind, clinicopathological study with a Brazilian population showed that people of African ancestry had a lower likelihood of accumulating amyloid plaques than Caucasians and that the APOE ε4 allele of African origin does not add an increased risk for AD compared to the APOE ε3 allele, as occurs with APOE of European origin.51 The gene discussed is APOE; the disease is Alzheimer disease.