MicroRNA is also important in the formation of drug resistance of osteosarcoma, for example the miR‐143 can inhibit autophagy but the expression of miR‐143 decreases in osteosarcoma and expression of ATG2B and LC3‐II increases, which can promote autophagy to generate chemoresistance in tumors.68, 69, 70. The gene discussed is ATG2B; the disease is osteosarcoma.