In addition, PD‐L2 can also induce autophagy through beclin‐1, as another upstream signal of the RhoA‐ROCK‐LIMK2 signaling pathway, beclin‐1 can also control cellular autophagy by regulating RhoA‐ROCK‐LIMK2 signaling pathway and also influence the tumor metastasis.59, 151, 152, 153. This evidence concerns the gene LIMK2 and neoplasm.