RIP1 plays a crucial role in necroptosis, TRA/GO reduces cIAP and Caspase‐8, the reduction of cIAP contributes to the formation of intracellular platform complexes, whereas the decrease in Caspase‐8 activity facilitates the formation of RIP1/RIP3/MLKL complexes, which promotes necroptosis and kills osteosarcoma cells.93, 94, 95, 96. The gene discussed is RIPK1; the disease is osteosarcoma.