POG1 exhibited unique enrichment of downregulated genes involved in pathways that regulate lipid metabolism for energy production (triacylglycerol degradation and stearate biosynthesis), growth & development (reelin signaling), and inflammation (the LPS/IL-1 mediated inhibition of RXR function pathway and a SPINK1 cancer pathway) (Figure 3B). Here, SPINK1 is linked to cancer.