SPINK1 and hepatocellular carcinoma: In contrast, POG1 mice also exhibited potential pro-inflammatory signatures, including increased expression of Saa2, an inflammatory response gene (61, 62); Mkrn2, a negative regulator of inflammation (63, 64); and Spink1, which has been shown to regulate redox homeostasis (50) and is overexpressed in ~70% of HCC patients (65).