The STAT3 signaling pathway (61–63) and suppressor of cytokine signaling 3 (SOCS3) (64) have been found to be crucial for certain miRNAs that regulate the growth, apoptosis, proliferation, invasion, drug resistance, and immune-modulatory function of GC cells (e.g., miR-125a reduces the expression of STAT3 to inhibit the migration and metastasis of GC cells (61), miR-665 directly inhibits SOCS3 activation to promote the cell growth, proliferation, and migration of GC cells (64)). This evidence concerns the gene SOCS3 and gastric cancer.