CEACAM5 and colorectal cancer: In the OSCER registry, the incidence of bone metastases in patients with colorectal cancer increased from 1.0% in the first year to 2.7% at 10.(4) An earlier study using the SEER database reported an incidence of bone metastases of 1.2%, with risk factors predictive of bone metastases including male gender, higher N stage, rectal site, elevated carcinoembryonic antigen, and lung and liver metastases.