MSH6 and endometrial cancer: It has been reported that the cumulative risk of inherited digestive cancers by the age of 70 was 46% for MLH1, 48% for MSH2 and 23% for MSH6 mutation (8), while the cumulative risk of endometrial cancer was 34% for MLH1、51% for MSH2、49% for MSH6 and 24% for PMS2 (9).