It had been discovered that the inactivation of core homologous recombination (HR) and HR-associated genes, such as BRCA1, BRCA2, CHEK2, PALB2, CDK12, CHD1, ATM, RAD54L, RAD51B, or PTEN, occurred in a considerable proportion of localized PCa, even more frequently in metastatic PCa (110). This evidence concerns the gene CDK12 and posterior cortical atrophy.