Interestingly, Zhou et al., found that tumour derived IL-1B increased the ability of mouse E0771 and Py8119 cells to migrate and invade to human pre-osteoblast OB1 cells, but exerted reduced migratory/invasive effects towards human umbilical vein endothelial cells (HUVEC) [7]. The gene discussed is IL1B; the disease is neoplasm.