Tulotta et al., found that genetic overexpression of IL-1B in ER + ve (T47D-IL-1B+ and MCF7-IL-1B+) and ER-ve (MDA-MB-231-IL-1B+) breast cancer cells led to both genotypic and phenotypic alterations associated with EMT (reduced E-cadherin, reduced γ-catenin and increased N-cadherin), compared with corresponding wildtype cells [4]. Here, IL1B is linked to breast carcinoma.