Thus, a high index of suspicion with a raised CRP level should be used to initiate empirical anti-fungal treatment till a proper histopathological report is procured. During the early stages of COVID-19 illness, CRP, an acute phase protein generated from hepatocytes as a result of interleukin (IL) 6 dysregulation, is a potent predictor of disease progression and poor outcomes [25]. The gene discussed is CRP; the disease is COVID-19.