The Hutchinson-Gilford progeria syndrome (HGPS) is a rare sporadic autosomal dominantdisorder characterized by accelerated aging [16].Earlier studies have demonstrated mTORC1 hyperactivity in HGPS, and inhibition of mTORC1effectively diminishes characteristic HGPS phenotypes, such as defects in nuclearmorphology (with deformation of the envelope) and accumulation of Progerin (thedisease-causing protein), suggesting a causal role for mTORC1 overactivation in HGPS[17, 18]. This evidence concerns the gene LMNA and Hutchinson-Gilford progeria syndrome.