Additionally, the causal relationship between genetically proxied inhibition of CACNB2 and the risk of depression did not reach a significant level either (common effect model: OR = 1.00, 95% CI: 1.00-1.01; random effect model: OR = 1.00, 95% CI: 1.00-1.01). The gene discussed is CACNB2; the disease is depressive disorder.