The results suggested that there was no causal relationship between genetically proxied inhibition of CACNB2 and the risk of depression (ieu-b-38: OR = 1.001, 95% CI: 0.995-1.007, P = 0.657; ukb-b-20175: OR = 0.958, 95% CI: 0.826- 1.111, P = 0.569; ebi-a-GCST90029011: OR = 1.035, 95% CI: 0.942-1.137, P = 0.474; ebi-a-GCST90018972: OR = 1.022, 95% CI: 1.217-0.859, P = 0.803) (Figure 2). This evidence concerns the gene CACNB2 and depressive disorder.