CACNB3 and major depressive disorder: Similarly, neither CACNA1D inhibition (ieu-b-38: OR = 1.011, 95% CI: 0.998-1.025, P = 0.099; ebi-a-GCST90029011: OR = 1.250, 95% CI: 0.932-1.676, P = 0.137; ebi-a-GCST90018972: OR = 1.210, 95% CI: 0.913-1.604, P = 0.185) nor CACNB3 inhibition (ieu-b-102: OR = 0.988, 95% CI: 0.969-1.007, P = 0.209) was significantly associated with the risk of depression (Figure 2).