In detail, up-regulation of bcl2 (sensitive [P<0.0001; P=0.0007]; INHR [P=0.001; P=0.001]; RifR [P=0.002; P=0.002]; MDR [P=0.004; P=0.001]; XDR [P=0.0001; P=0.001]) and rb1 (sensitive [P=0.0006; P=0.001]; INHR [P=0.01; P<0.0001]; RifR [P=0.001; P=0.0007]; MDR [P=0.002; P=0.003]; XDR [P=0.003; P=0.005]) in infected A549 by all sensitive and resistance Mtb isolates was detected 24 and 48 hr post infection, respectively. Here, RB1 is linked to infection.