In an expression profile of miRNA in the kidney of DKD model mice, it was found that the expression of miR-703 and miR-466f in the kidney of DKD mice was significantly increased, which is consistent with our results.[45] Studies have found that miR-132-3p promotes cell proliferation by directly regulating BCL2L11, an apoptosis activator, leading to tuberous sclerosis.[46] In addition, miR-132-3p could also promote oxidative stress by targeting FOXO3, leading to autosomal dominant polycystic kidney disease.[47] However, there is no report on the above five miRNAs in DKD. This evidence concerns the gene FOXO3 and tuberous sclerosis.