REN and diabetic kidney disease: Interestingly, although the incidence of diabetes is increasing, multiple studies have demonstrated that strict blood glucose control and the use of renin–angiotensin system (RAS) blockers cause a significant decline in the incidence of DKD.[2] RAS blockers used in DKD not only reduce proteinuria, but also delay disease progression, which is only partly explained by their hemodynamic effects.[3]