HLF and diabetic kidney disease: In addition, DBP, TEF, HLF, and other CLOCK control genes are also direct target genes of BMAL1–CLOCK heterodimer and participate in the regulation of circadian rhythm.[18] It has been reported that BMAL1-knockout mice developed circadian rhythm disorders and metabolic damage, including impaired glucose and fatty acid metabolism, which are potential factors that accelerate the development of DKD.[19]