Irbesartan effectively prevented the downregulation of miR-133a and miR-29b in cardiomyocytes and inhibited the expression of Col1A1 and myocardial fibrosis.[44] In order to explore whether the therapeutic effect of irbesartan on DKD involved miRNAs, we also predicted miRNAs related to key DEGs. The gene discussed is COL1A1; the disease is Myocardial fibrosis.