Molecular assessment of tumor tissue suggests somatic pathogenic variants in the genes mastermind like transcriptional coactivator 3 (MAML3), alpha thalassemia/mental retardation syndrome X (ATRX), and cold shock domain-containing E1 (CSDE1) are also associated with metastatic behavior [55-57]. The gene discussed is CSDE1; the disease is Alpha-thalassemia.