The nonhistological variables were tumor size 8.1 cm or larger (OR = 7.5), extra-adrenal tumor location (OR = 6.75), and PV in the SDHB gene (OR = 6.33), and the histological variables were necrosis (OR = 36.6), more than 3 mitoses/10 HPF (OR = 19.33), high cellularity (OR = 7.83), and extension into adipose tissue (OR = 4.42). The gene discussed is SDHB; the disease is adrenal gland neoplasm.