GLP1R and obesity due to melanocortin 4 receptor deficiency: GLP-1 was chosen as a study example, sinceit is now being studied as diabetes and obesity therapy.26,27 Earlier theoretical and experimental studies supported our GLP-1hotspot residue selection.9,28 Our MD simulationsshowed a stable binding mode of the D-GLP-1_diff_Acetylated coupledto the GLP-1R.