NFKB1 and cholangiocarcinoma: For instance, O-GlcNAcylation is responsible for controlling the metastatic abilityof CCA cells via nuclear translocation of NF-κB and heterogeneousnuclear ribonucleoprotein-K (hnRNP-K).16,17 Therefore,understanding the nuanced impact of O-GlcNAcylationassociated with cholangiocarcinoma yields insight into its regulationof cancer-relevant proteins, unveils novel therapeutic targets, andprovides scientific paradigm for effective strategies in CCA therapeutics.