PTGS2 and early-onset autosomal dominant Alzheimer disease: COX-2activity in the brain is implicated in many neurodegenerativeand psychiatric disorders that comprise a significant portion of themain contributors to global disease burden.6−9 However, the specific role ofCOX-2 in the central nervous system (CNS) remains unclear, even amidststrong associations of increased COX-2 expression with the pathologyof neurodegenerative diseases, including Alzheimer’s disease(AD)10,11 and multiple sclerosis (MS).12 Both COX-2 and COX-2 metabolites are elevatedin the post-mortem brain tissue of patients diagnosed with these neurodegenerativediseases.