Additionally, usingmouse models of Huntington’s disease(HD) and post-mortem human brain tissue from donors with HD, we showthat COX-2 protein levels increase in disease-affected brain regionsand that increases are likely to be driven by increased expressionin microglia specifically, suggesting that our tracer has potentialutility as a clinical indicator for this disease indication. This evidence concerns the gene PTGS2 and Huntington disease.