Cyclooxygenase-2 (COX-2) is an enzyme that plays a pivotalrolein peripheral inflammation and pain via the prostaglandin pathway.In the central nervous system (CNS), COX-2 is implicated in neurodegenerativeand psychiatric disorders as a potential therapeutic target and biomarker.However, clinical studies with COX-2 have yielded inconsistent results,partly due to limited mechanistic understanding of how COX-2 activityrelates to CNS pathology. The gene discussed is PTGS2; the disease is psychiatric disorder.