Tau dysfunction and amyloid-β plaques both disrupt the AIS and alter its length and position (Marin et al., 2016; Hatch et al., 2017; Antón-Fernández et al., 2022), and the AIS cytoskeleton is destabilized in Alzheimer’s disease patients (Sohn et al., 2016). This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.