NF1 and breast carcinoma: These studies revealed that women with NF1 have a 5-7-fold increased risk of developing breast cancer at a younger age (Madanikia et al., 2012; Wang et al., 2012; Seminog and Goldacre, 2015; Uusitalo et al., 2016; Uusitalo et al., 2017; Landry et al., 2021).