The role of NF1 has been commonly studied in the context of Neurofibromatosis type 1 (NF1), a tumor predisposition syndrome affecting one in 3,000 live births caused by mutations in the NF1 gene (Rasmussen and Friedman, 2000; Lammert et al., 2005; Griffiths et al., 2007; Evans et al., 2010; Yap et al., 2014; Mo et al., 2022). The gene discussed is NF1; the disease is BAP1-related tumor predisposition syndrome.