In the field of NF1 research, studies evaluating collagen in NF1-mediated tumorigenesis have only been conducted in the context of skin wound healing and neurofibromas (Peltonen et al., 1986; Atit et al., 1999; Brosseau et al., 2021; Kershner et al., 2022). Here, NF1 is linked to plexiform neurofibroma.