SERPINE2 and inflammatory bowel disease: However, MMP8, CXCL2, CXCL3, LCN2, SERPINE2, and CCL3 were not upregulated in the colon of patients with active IBD when compared to non-IBD subjects and patients with IBD in the inactive stage (Figure 9), but we should bear in mind that non-IBD subjects and patients with IBD in the inactive stage do not have health conditions, and these genes could be upregulated in these two groups of patients.