Quantitative RT-PCR showed that the expression levels of MMP3, MMP10, IL6, IL1B, S100A8, S100A9, SERPINE1, and CSF3 were higher in the colon of patients with active IBD than non-IBD subjects and patients with IBD in the inactive stage, and the expression level of IL1A was downregulated in patients with IBD in the inactive stage when compared to patients with active IBD (Figure 9). The gene discussed is IL1B; the disease is inflammatory bowel disease.