The stimulation of the DNA sensor GMP-AMP synthase (cGAS) in RA RA-FLS by macrophage-derived microvesicles (METs) from HP-1 cells triggers the activation of the PI3K/Akt signaling pathway, leading to enhanced proliferation, migration, invasion, and expression of inflammatory cytokines in RA-FLS. The gene discussed is AKT1; the disease is rheumatoid arthritis.