It is noteworthy that, besides the values that were prognostic in our cohort, several other circulating factors are directly involved in the modulation of an effective anti-tumor response and, therefore, could exert a prognostic role when ICIs release the brakes for the immune system activation (e.g., IL-10, IL-1, TNF-α): disappointingly, our results were not statistically relevant about these further factors, and from previous studies, no conclusive survival data are retrievable. The gene discussed is TNF; the disease is neoplasm.