IFNG and macrophage activation syndrome: Likewise, IFN-γ has also been shown to promote inflammation in mouse models of and/or patients with psoriasis (31), alopecia areata (32), and hyperinflammatory diseases, such as primary hemophagocytic lymphohistiocytosis, and several forms of secondary hemophagocytic lymphohistiocytosis, such as macrophage activation syndrome (33).