It acts as a co-receptor for the B cell antigen receptor (BCR) and plays a crucial role in B-cell signaling by enhancing cell proliferation, mitogen-activated protein kinase activity, and calcium release synergistically in B-cells when co-ligated with the BCR (147).B-cell lymphoma, cancer affecting lymphocytes, can present as a solid tumor in lymph nodes or other tissues, involving the bone marrow and circulating in the blood (29). The gene discussed is BCR; the disease is B-cell non-Hodgkin lymphoma.