PTPN11 and neoplasm: Interestingly, the CD68+SHP2+ subset proportion was positively correlated with the CD68+CD206+ subset within TME (r = 0.602, P < 0.0001, Figure 4E), tumor (r = 0.618, P < 0.0001, Figure 4F) and stroma (r = 0.618, P < 0.0001 Figure 4G).