Bilirubin levels affect patients with cholangiocarcinoma’s prognosis in several ways: Patients with hilar cholangiocarcinoma with higher bilirubin levels at diagnosis may not benefit from surgery (34); The albumin bilirubin (ALBI) grade, which combines bilirubin and albumin levels, is an independent prognostic factor for OS and PFS in intrahepatic cholangiocarcinoma (35, 36). Here, ALB is linked to cholangiocarcinoma.