Bilirubin levels affect patients with cholangiocarcinoma’s prognosis in several ways: Patients with hilar cholangiocarcinoma with higher bilirubin levels at diagnosis may not benefit from surgery (34); The albumin bilirubin (ALBI) grade, which combines bilirubin and albumin levels, is an independent prognostic factor for OS and PFS in intrahepatic cholangiocarcinoma (35, 36). The gene discussed is ALB; the disease is hilar cholangiocarcinoma.