Thus, the extent of splenomegaly and lymphadenopathy was comparable between female WT- and Ackr2-/- B6lpr mice, as were numbers of CD3+CD4-CD8- autoreactive T cells in spleen, lymph nodes and kidneys, levels of circulating lupus autoantibodies and the extent of glomerular IgG deposition. Here, ACKR2 is linked to Splenomegaly.