TP53 and neoplasm: p53 is a transcription factor that regulates the cellular responseto stress, while MDM2 downregulates its activity through a negativefeedback loop by binding to the α-helical transactivation domainnear the N-terminus of p53.38−40 Suppressed p53 cannot regulategrowth arrest and cell death in the presence of DNA damage and thusdirectly contributes to tumor development, malignant disease progression,resistance to treatment, and poor prognosis.