It was observed that sh-HLA-DRB5 increased the PLT count in the Control group mice (Figure 2d, p < 0.05), and PLT count was more in the ITP + sh-HLA-DRB5 group than in the ITP + vector group (Figure 2d, p < 0.001). This evidence concerns the gene HLA-DRB5 and autoimmune thrombocytopenic purpura.