It is evidenced that PLT autoantibodies are present in about 70% ITP patients, which bind to autoantigens (GPs IIb/IIIa, GPIbIX) on the PLT surface and lead to premature clearance of antibody-opsonized PLT by splenic macrophages or dendritic cells [17]. Here, NBEAL2 is linked to autoimmune thrombocytopenic purpura.