ICAM-1 can mediate the interpore drug delivery system or target certain special nanoparticles to treat TNBC [29,30], etc. The interaction mechanism between ICAM-1 and different molecules and pathways remains unclear, the research on ICAM-1’s impact on the prognosis of breast cancer is incomplete, and the role of ICAM-1 in the diagnosis and treatment of breast cancer has not yet been fully realized. This evidence concerns the gene ICAM1 and breast cancer.