Based on the findings of cell type-specific regulatory activity, the most active TFs in each of the 4 cardiomyopathy fibroblast subpopulations, including NR3C1 (C0 THBS4+ Fibroblasts), KLF4 (C1 LINC01133+ Fibroblasts), FOSB (C2 FGF7+ Fibroblasts), FOS (C3 AGT + Fibroblasts) (Figure 7). The gene discussed is KLF4; the disease is cardiomyopathy.