Differences in stemness gene expression and differences in transcriptional regulatory activity between C3 AGT + Fibroblasts and other subpopulations of cardiomyopathic fibroblasts may provide a novel perspective that the differential gene expression, stemness differences, and transcriptional regulator differences in C3 AGT + Fibroblasts may influence cardiomyopathy outcomes such as myocardial fibrosis. This evidence concerns the gene C3 and cardiomyopathy.