ADAM17 and familial dilated cardiomyopathy: Because the expression and activity of ADAM17 in the myocardium of the DCM mice were elevated, and cardiac fibroblast differentiation is a salient feature of DCM, we investigated the effects of ADAM17 deficiency in cardiac fibroblasts and the use of the aldosterone receptor antagonist, eplerenone on the mice with DCM in vivo.