Because the expression and activity of ADAM17 in the myocardium of the DCM mice were elevated, and cardiac fibroblast differentiation is a salient feature of DCM, we investigated the effects of ADAM17 deficiency in cardiac fibroblasts and the use of the aldosterone receptor antagonist, eplerenone on the mice with DCM in vivo. The gene discussed is NR3C2; the disease is familial dilated cardiomyopathy.