The mechanism of its action against lipid and glucose metabolism dysfunction was investigated after treatment with 300 mg/kg puerarin for 4 weeks in T2DM rats, fasting insulin, glycated hemoglobin, glucose tolerance and lipid profile were significantly normalized recovery and the expression level of PI3K, p-AKT, and p-FoxO1 was increased while PEPCK and G6Pase decreased (Liu et al., 2021). This evidence concerns the gene FOXO1 and type 2 diabetes mellitus.