FOXO1 and type 2 diabetes mellitus: Additionally, the mechanistic basis of curcumin is a potential therapeutic strategy for the protection of pancreatic β-cells in T2DM, and it shows that curcumin protected MIN6 β-cells from palmitate-induced apoptosis by modulating the PI3K/AKT/FoxO1 signaling pathway and the mitochondrial survival pathway (Hao et al., 2015).