In addition, esculin restored blood glucose level and glucose tolerance in STZ-induced diabetic mice and dexamethasone-induced diabetic mice, and enhance the phosphorylation of AKT in C2C12 myotubes, indicating a potential for the improvement of insulin resistance (Kang et al., 2014; Mo et al., 2019). The gene discussed is AKT1; the disease is Insulin resistance.