Apigenin significantly increases glucose consumption and glycogen synthesis, suppresses the production of ROS and AGEs, and improves insulin resistance in IR-HepG2 cells, and elevated the level of protein expression of IRS-1, IRS-2, PI3K, and p-AKT is observed in IR-HepG2 cells (Miao et al., 2023). This evidence concerns the gene IRS1 and Insulin resistance.