Available evidence from multiple research in the area of diabetes suggests that GLUT4 mediates insulin-dependent glucose uptake and that the PI3K/AKT pathway regulates the movement of GLUT4 between the plasma membrane and intracellular vesicles in an insulin-dependent manner, and thus GLUT4 dysfunction could induce insulin resistance (Chang et al., 2023). The gene discussed is AKT1; the disease is diabetes mellitus.