INS and type 2 diabetes mellitus: Ginsenosides, obtained from ginseng, have been demonstrated to possess anti-diabetic activity, such as Ginsenoside Rb2, Ginsenoside Rg5, etc. Ginsenoside Rg5 may be a potential natural product in the treatment of T2DM for the first time, which can remarkably improve glucose and lipid metabolism, increase insulin secretion, and protect damaged tissues in T2D mice.