Ginsenoside Rb2 can jointly improve insulin resistance of 3T3-L1 adipocytes and DIO mice by regulating various pathways such as PI3K/AKT, MAPK and NF-κB, showing various therapeutic effects such as upregulation of inflammatory factors, reduction of fat accumulation and improvement of glucose metabolism (Dai et al., 2018). This evidence concerns the gene AKT1 and Insulin resistance.