Besides, orally given baicalein (400 mg/kg/day) to C57BL/6 mice induced by a high-fat diet, the disorders of dyslipidemia, fatty liver, diabetes and insulin resistance in mice were effectively normalized after oral medication and all of these improvements were mediated by inhibition of the MAPKs pathway and activation of the IRS1/PI3K/AKT pathway involving multiple intracellular signaling pathways (Pu et al., 2012). Here, IRS1 is linked to diabetes mellitus.