In vivo, HM-chromanone can reduce hyperglycemia and ameliorate dyslipidemia in C57BL/Ksj-db/db mice, the effect of 30 mg/kg HM-chromanone for 6 weeks on levels of HbA1c, plasma insulin, HOMA-IR and serum lipid significantly normalized. This evidence concerns the gene INS and Hyperglycemia.