Embelin treatment of HFD-STZ-induced T2DM rats shows that it regulates glucose uptake by regulating GLUT4 transposition and activation in epididymal adipose tissue mediated by insulin-dependent PI3K/AKT pathway, manifesting that it plays a positive role in improving adipose tissue insulin sensitivity, enhancing blood glucose control, protecting β cells from damage and maintaining adipose tissue glucose homeostasis in animal models (Gandhi et al., 2013). The gene discussed is INS; the disease is type 2 diabetes mellitus.