IL-6, a pleiotropic cytokine, is produced by various immune cells (monocytes, macrophages, T and B lymphocytes), epithelial, fibroblast, glia, adipocytes, and tumor cells within the tumor microenvironment (TME) (Taniguchi and Karin, 2014a; Crusz and Balkwill, 2015). This evidence concerns the gene IL6 and neoplasm.