KEGG analysis showed LBT could affect the cytokine-cytokine receptor interaction, herpes simplex virus infection, and allograft rejection related genes such as Tnf, Ccl5, and Il1b. Our results demonstrated that LBT protects mice against LPS-induced sepsis by downregulating the production of inflammatory cytokines in macrophage. The gene discussed is TNF; the disease is Sepsis.