In support of the aforementioned essentiality, the irreversibly and progressively lost function of Piezo2 in proprioceptive terminals is suggested to be one critical underlying process in the amyotrophic lateral sclerosis (ALS) pathomechanism (Sonkodi, 2021; Sonkodi and Hortobagyi, 2022; Sonkodi, 2023b; Sonkodi, 2024). This evidence concerns the gene PIEZO2 and amyotrophic lateral sclerosis.