Under ARPI pressure, AR mRNA detaches from polysomes (PSs) and is recruited by RNA-protein stress granules (SGs), resulting in reduced translation of AR. These SGs promote the separation of m6A-modified or unmodified AR mRNA from its binding proteins YTHDF3 and G3BP1, protecting PCa tumor cells (Somasekharan et al., 2022). The gene discussed is AR; the disease is posterior cortical atrophy.