Furthermore, the cancer-promoting factor METTL3 and its upstream cofactor YTH domain family 2 protein (YTHDF2), were identified as the key “writer” and “reader” of m6A modification, facilitating mRNA degradation of tumor suppressor lipid phosphatase and NK3 homeobox 1 and promoting the proliferation and migration of PCa cells. Here, METTL3 is linked to posterior cortical atrophy.