We tested whether cellular senescence is associated with AD characteristics (Global AD pathology: a quantitative summary of AD pathology derived from counts of three AD pathologies: neuritic plaques, diffuse plaques, and neurofibrillary tangles; Braak stage: a semiquantitative measure of distribution and severity of neurofibrillary tangle pathology; tangle density: immunohistochemistry for phosphorylated tau; overall amyloid level: immunohistochemistry for amyloid beta) and other AD risk factors, such as APOE4, sex, and ABCA1 mRNA expression. This evidence concerns the gene APOE and Alzheimer disease.