Consistent with the detection of these msiCAT-tailing signals, increased NEMF (Nuclear Export Mediator Factor) levels (10) and decreased ANKZF1 (Ankyrin Repeat and Zinc-finger Peptidyl tRNA Hydrolase 1) expression (11) were observed in patient-derived GSCs (Figure 1B), further indicative of enhanced CAT-tailing activation, mirroring bioinformatics findings in GBM samples. The gene discussed is CAT; the disease is glioblastoma.