ASCC1 and glioblastoma: Our analysis of transcriptomic data from a cohort of 153 GBM patients and 206 healthy controls, sourced from public datasets, revealed significantly elevated expression (logFC (fold change) > 1; adj.P.Val < 0.001) of RQC pathway genes, such as ABCE1, ASCC1–3, RACK1, and VCP, in GBM cells(39).