These models were chosen to control for tumor location (DIPG is within the CNS, ALL is primarily outside of but can involve the CNS, and osteosarcoma is exclusively outside of the CNS), CAR T cell target (GD2, CD19 or B7H3), and degree of cytokine release associated with tumor clearance (Figures 1A–1E). The gene discussed is CD276; the disease is acute lymphoblastic leukemia.