CRH and major depressive disorder: Here we further characterized neurobehavioral changes associated with this model where we observed that this model of mTBI results in similar alterations in LHb excitability, CRF-regulation of LHb activity and behavioral responses to sucrose splash and looming threat-related stimuli in male and female mice (with a few sex differences in intrinsic plasticity and social deficits), further supporting the translational utility of this mTBI model in both sexes for investigation of reward/motivational circuit dysfunction relevant to mTBI-related depression, anxiety and PTSD in humans.