Altogether, we provided several lines of evidence for translational validity of a preclinical model of mTBI in male and female mice that is associated with LHb hyperactivity and intra-LHb CRF dysregulation, associated with a lack of motivation in self-care, disrupted social behavior and aberrant threat responses that are core symptoms of many psychiatric conditions including depression, anxiety and PTSD. Here, CRH is linked to major depressive disorder.