MUC2 and Crohn disease: Thus, we can imagine that the thicker mucus layer observed in the present study would exhibit an altered structure of MUC2 glycoproteins, leading to the observed functional modifications leading and loss of mucus viscoelastic properties and then consequently a loss of protective functions, as already observed in Crohn’s disease.47 These authors demonstrated that these effects were attributed to a reduction in the oligosaccharide chain length by 50% of MUC2.