Among these predicted kinases, IKKε (IKBKE) and PKCθ (PRKCQ) were predicted to have significantly higher activity in PAK4 KO tumour at one week in comparison to WT tumour (Fig. S6g) indicating a higher activity of T cell receptor pathway in PAK4KO as both IKKε and PKCθ are activated upon activation of T cell receptor [26–28]. The gene discussed is IKBKE; the disease is neoplasm.