Shi et al.42 found that Andro can impede colorectal carcinoma cell growth by arresting them in the G1-S phase, promoting the expression of p53, p21, and p16, which in turn suppressed the activity of Cdk2, Cdk4, and phosphorylation of retinoblastoma (Rb). The gene discussed is TP53; the disease is colorectal carcinoma.