COX is divided into two isoforms, COX-1 and COX-2 while COX-1 is constitutively expressed in most tissues and appears to be involved in housekeeping functions, on the other hand, COX-2 is not found in most normal tissues but is activated by cytokines, growth factors, carcinogens, and tumor promoters27–29. Here, PTGS2 is linked to neoplasm.