CCN2 and cancer: Some of these are Connective tissue growth factor, also known as Cellular communication network factor 2 (CTGF/CCN2), which mediates fibrosis in cardiomyocytes and regulates proliferation, cell adhesion and angiogenesis51 or Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1), protein CYR61 and DNA (cytosine-5)-methyltransferase 1 (DNMT1) those can be found in cancer cell-derived EVs as well in which they play a role in EV-induced angiogenesis, proliferation, invasion or in vivo metastasis formation of recipient cells52–54.