NOTCH1 and lung cancer: For instance, Xie and colleagues uncovered that Notch1 promotes the expression of glycolytic genes through interaction with histone acetyltransferases p300 and pCAF.416 Moreover, Notch1 signaling and PDZ-binding motif form a positive feedback loop that elevates extracellular lactate levels, inhibiting the activity of cytotoxic T cells and ultimately contributing to the malignant behavior of lung cancer.