DLL4 and neoplasm: Another study has reported that JAG1 may mediate the long intergenic non-coding RNA linc-OIP5 to regulate the DLL4/Notch/NRP1 signaling pathway in human umbilical vein endothelial cells, affecting angiogenesis in the breast cancer microenvironment.371 However, further experiments are needed to explore how JAG1 interacts with Notch ligands such as DLL4 to regulate tumor angiogenesis.