NOTCH1 and pachyonychia congenita: Inhibition of Notch signaling is reported to enhance the chemosensitivity of PC to GEM by activating the intrinsic apoptotic pathway.473 Glioma amplified sequence 41 (GAS41) is reported to be a novel regulator of Notch signaling by controlling H2A.Z deposition.474 Han et al. found that GAS41 binds to H2A.Z.2 to activate Notch1 signaling and its downstream mediators, driving PC stemness and GEM resistance.475 Given the function of widely activated Notch signaling in chemotherapy resistance of PC cells, Notch signaling is expected to become a potential therapeutic target for PC.