NOTCH1 and pachyonychia congenita: Zhai et al. identified a new microprotein, Notch1 degradation-associated regulatory polypeptide (N1DARP), encoded by LINC00261.476 N1DARP promotes N1ICD degradation by destroying USP10-N1ICD interactions, thereby suppressing chemoresistance in Notch1-overactivated PC.