ASB2 and cancer: For instance, oncogenic Notch signaling facilitates T-ALL cell proliferation by activating nuclear factor-kappa B (NF-κB) through Asb2 mediation.13 Additionally, activated Notch signaling contributes to the acquisition of stem-like properties in esophageal adenocarcinoma.14 The pivotal role of Notch signaling in cancer biology has garnered significant attention, leading to the exploration of targeted cancer therapies based on Notch signaling.