For instance, oncogenic Notch signaling facilitates T-ALL cell proliferation by activating nuclear factor-kappa B (NF-κB) through Asb2 mediation.13 Additionally, activated Notch signaling contributes to the acquisition of stem-like properties in esophageal adenocarcinoma.14 The pivotal role of Notch signaling in cancer biology has garnered significant attention, leading to the exploration of targeted cancer therapies based on Notch signaling. The gene discussed is NFKB1; the disease is cancer.