Recent research revealed that the expression of Notch1 and Notch3 was significantly increased in glioblastoma and promoted tumor growth activity through the NF-κB pathway.267,268 In addition, DLL3 was found to be up-regulated in IDH1 mutant gliomas and was associated with a better prognosis.269 Overall, the differential expression pattern of Notch1–4 receptors can be used as a marker of glioma differentiation and a possible prognostic factor.270 Functionally, Notch signaling is involved in glioma progression through complex mechanisms. Here, NOTCH1 is linked to central nervous system cancer.