RBPJ and central nervous system cancer: CBF1, also known as RBPJ, has been identified as a participant in the EMT-like phenotype of glioma cells.353 Maciaczyk et al. demonstrated that inhibiting CBF1 can impede EMT activators, such as zinc finger E-box-binding homeobox 1, resulting in decreased cell invasiveness and chemoresistance in EMT-like glioblastoma cells.