Neuroblastoma is a neuroendocrine tumor originating from the sympathetic nervous system, characterized by genetic, morphological, and clinical heterogeneity.275 Advances in high-throughput technology have contributed to understanding the genetic changes and molecular pathways involved in the pathogenesis of neuroblastoma, including MYCN amplification, PHOX2B mutation, the PI3K/AKT/mTOR pathway, and Notch signaling. This evidence concerns the gene PHOX2B and neuroblastoma.