In a recent study by Jackstadt et al., the activation of Notch1 signaling in mouse intestinal epithelium was found to reshape the TME of CRC, showing a close association with poor prognosis.442 Moreover, activated Notch1 signaling was shown to promote the metastasis of KrasG12D-driven serrated cancer through TGF-β-dependent neutrophil recruitment. Here, NOTCH1 is linked to colorectal carcinoma.