IDH1 and central nervous system cancer: Notch1 mutations were identified in diffuse lower-grade gliomas, Notch1 and Notch2 mutations were identified in IDH1-mutant gliomas, and grade II and III gliomas carried Notch1–4 mutations.263–265 Furthermore, Halani et al. uncovered that Notch1 mutations were related to disease progression and shorter survival in oligodendroglioma.266 Accumulating studies have highlighted the importance of the Notch signaling pathway in glioma malignancy.