In a stable Notch1-activated cervical cancer HeLa cell line established by Laura and colleagues, activation of Notch1 led to apoptosis, cell cycle arrest, and tumor suppression.257 Mechanistically, Notch1-mediated tumor suppression in cervical cancer may be partly achieved by up-regulating somatostatin (SST) signaling. The gene discussed is SST; the disease is cervical carcinoma.