Another study revealed that in hepatitis B virus (HBV)-related HCC tissues, the expression of Notch1 or Notch4 was associated with HBV X protein (HBx), suggesting that HBx may play a role in carcinogenesis by regulating the Notch pathway.70 Notch2 is closely linked to liver cancer occurrence. The gene discussed is NOTCH1; the disease is hepatocellular carcinoma.