JAG1 and neoplasm: JAG1 promotes the EMT process of OC by crosstalk with the JAK/STAT3 pathway, further enhancing the invasion and migration ability of platinum-resistant OC.245 In OC, tumor-associated neutrophils activate JAG2 to coordinate the intratumoral IL-8-driven immune evasion microenvironment.246 Resistance to standard treatment regimens is one of the main reasons for the poor prognosis of OC.