Upregulated expression of JAG2 was also noted in HCC tissues and was associated with poor clinicopathological features.78 Targeted inhibition of JAG1 and JAG2 is expected to act as a tumor suppressor in HCC.79 In conclusion, these studies suggest that Notch family members may serve as potential prognostic indicators in patients with HCC. The gene discussed is JAG2; the disease is hepatocellular carcinoma.