DLL4 and neoplasm: The Notch ligand, JAG1, exhibits significantly lower levels in GC tissues than in non-tumor tissues, and its reduced level in both tumors and non-tumors is associated with poor outcomes.98 However, no significant difference was observed between DLL4 expression and clinicopathological features and OS.99 Further research is needed to explore the mechanisms underlying abnormally activated Notch signaling in GC tumorigenesis.