The deregulated expression of Notch receptors and their ligands has been noted in HCC.67,68 Ahn and colleagues observed cytoplasmic expression of Notch1, Notch3, and Notch4 in 50.3%, 20.8%, and 59.7% of 288 HCC cases, respectively.69 Notch1 expression and Notch4 overexpression may independently predict poor survival in HCC. The gene discussed is NOTCH3; the disease is hepatocellular carcinoma.