JAG2 and non-small cell lung carcinoma: The levels of other Notch ligands, including JAG1, JAG2, and DLL1, in NSCLC were also observed to be lower than that in normal lung tissue.131 Furthermore, DLL4 and Notch1 emerged as independent prognostic factors for NSCLC but exhibited varying effects in LUAD and LUSC.132 The inconsistent results across studies may stem from small sample sizes or variations in sample sources.