Positive expressions of Notch1 and DLL4 were identified in PTC, showing a significant correlation with tumor invasion, metastasis, and poor prognosis.307,308 Conversely, the expression of Notch3 decreased in FTC specimens exhibiting reduced differentiation and increased malignancy, linking to clinicopathological features associated with poor prognosis.309. This evidence concerns the gene NOTCH3 and neoplasm.