Several oncogenic proteins, such as MYC, AURKB, and mutant p53, have been found to educate a tumor-promoting microenvironment through the secretion of EVs (Cooks et al., 2018; Novo et al., 2018; Kilinc et al., 2021), whereas tumor suppressors foster a tumor-suppressive microenvironment via EVs (Schuldner et al., 2019; Zhang et al., 2020b). This evidence concerns the gene TP53 and neoplasm.