Also, tumor-supporting cells, like cancer-associated fibroblasts, release EVs containing Annexin A6, miR-21, or lncRNA H19, which contributes to the development of stem-like properties and resistance to chemotherapy in tumor cells (Au Yeung et al., 2016; Ren et al., 2018; Uchihara et al., 2020). Here, ANXA6 is linked to neoplasm.